منابع مشابه
Loperamide abuse and cardiotoxicity
With increasing restrictions and safety protocols implemented in prescribing opioids, there has been an increased incidence of recreational abuse of over-thecounter medications, including loperamide. Loperamide is a peripherally-acting μ-opioid receptor agonist in the gastrointestinal tract which, if taken at high doses, can cross the blood-brain barrier to produce euphoria and analgesia effects.
متن کاملHigh-dose loperamide abuse–associated ventricular arrhythmias
Charles W. O’Connell, MD, Amir A. Schricker, MD, MS, Aaron B. Schneir, MD, Imir G. Metushi, PhD, Ulrika Birgersdotter-Green, MD, Alicia B. Minns, MD From the Division of Medical Toxicology, Department of Emergency Medicine, University of California San Diego, San Diego, California, Department of Emergency Medicine, Veterans Association San Diego, La Jolla, California, Division of Cardiovascular...
متن کاملVentricular Tachycardia Triggered by Loperamide and Famotidine Abuse
A 32-year-old male developed recurrent ventricular tachycardia after taking mega doses of loperamide and famotidine in order to experience an opiate-like euphoric effect. He was taking up to 200 mg of loperamide and multiple doses of famotidine each day. He developed palpitations and syncope. Electrocardiography demonstrated ventricular tachycardia and QT interval prolongation (corrected QT int...
متن کاملElectrocardiographic Abnormalities, Malignant Ventricular Arrhythmias, and Cardiomyopathy Associated With Loperamide Abuse.
A 20-year-old man presented with recurrent syncope and abnormal electrocardiogram (ECG). His evaluation revealed a prolonged QT interval >600 milliseconds, witnessed torsades de pointes (TdP), and dilated cardiomyopathy. At his initial admission, an ICD was implanted and atrial pacing at 80 beats per minute suppressed ventricular arrhythmias. The patient was readmitted with device infection and...
متن کاملNotes from the Field: Cardiac Dysrhythmias After Loperamide Abuse - New York, 2008-2016.
Loperamide is an over-the-counter antidiarrheal with opioid-receptor agonist properties. Recommended over-the-counter doses (range = 2-8 mg daily) do not produce opioid effects in the central nervous system because of poor oral bioavailability and P-glycoprotein efflux* of the medication (1); recent reports suggest that large doses (50-300 mg) of loperamide produce euphoria, central nervous sys...
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ژورنال
عنوان ژورنال: Canadian Medical Association Journal
سال: 2017
ISSN: 0820-3946,1488-2329
DOI: 10.1503/cmaj.161421